Article

Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

2024-04-17

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B-cell malignancies, but many patients relapse due to failed expansion and/or progressive loss of CAR-T cells. We recently reported a strategy to potently restimulate CAR-T cells in vivo , enhancing their functionality by administration of a vaccine-like stimulus comprised of surrogate peptide ligands for a CAR l...

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Literature Corpus work: f3ca3b36-6866-51cc-88cc-a24b94562a6a
DOI: 10.1101/2024.04.16.589780

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