Article
Development of a CD8 co-receptor independent T-cell receptor specific for tumor-associated antigen MAGE-A4 for next generation T-cell-based immunotherapy.
Journal for immunotherapy of cancer - 1 Mar 2021
Davari Kathrin, Holland Tristan, Prassmayer Laura, Longinotti Giulia, Ganley Kenneth P, Pechilis Lisa J, Diaconu Iulia, Nambiar Prashant R, Magee Michael S, Schendel Dolores J, Sommermeyer Daniel, Ellinger Christian
Abstract excerpt
BACKGROUND: The cancer-testis antigen MAGE-A4 is an attractive target for T-cell-based immunotherapy, especially for indications with unmet clinical need like non-small cell lung or triple-negative breast cancer. METHODS: An unbiased CD137-based sorting approach was first used to identify an immunogenic MAGE-A4-derived epitope (GVYDGREHTV) that was properly processed and presented on human leukocyte antigen...
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