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Article

Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype.

Human molecular genetics - 1 Nov 2017

Yao Likun, Chen Jing, Wu Xiaotong, Jia Shunji, Meng Anming

Abstract excerpt

Cell Division Cycle 6 (Cdc6) is a component of pre-replicative complex (preRC) forming on DNA replication origins in eukaryotes. Recessive mutations in ORC1, ORC4, ORC6, CDT1 or CDC6 of the preRC in human cause Meier-Gorlin syndrome (MGS) that is characterized by impaired post-natal growth, short stature and microcephaly. However, vertebrate models of MGS have not been reported. Through N-ethyl-N-nitrosourea...

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Source

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Identifiers

PMID: 28985365
DOI: 10.1093/hmg/ddx305
PMCID: PMC5886151

Genes

CDC6
CDT1
ORC1
ORC4
ORC6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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