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Article

Requirement of CDC45 for postimplantation mouse development.

Molecular and cellular biology - 1 Jul 2001

Yoshida K, Kuo F, George E L, Sharpe A H, Dutta A

Abstract excerpt

CDC45 is required for the initiation of DNA replication in Saccharomyces cerevisiae and functions as a DNA polymerase alpha loading factor in Xenopus, but its role in mammalian DNA replication is unknown. To investigate the genetic and physiological functions of CDC45, we used a gene targeting strategy to generate mice lacking a functional CDC45 gene. Homozygous mutant mice lacking a functional CDC45 gene...

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Identifiers

PMID: 11416137
DOI: 10.1128/MCB.21.14.4598-4603.2001
PMCID: PMC87121

Genes

CDC45

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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