Article
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations.
Nucleic acids research - 5 Jul 2022
Matic Marin, Singh Gurdeep, Carli Francesco, De Oliveira Rosa Natalia, Miglionico Pasquale, Magni Lorenzo, Gutkind J Silvio, Russell Robert B, Inoue Asuka, Raimondi Francesco
Abstract excerpt
In this study we show that protein language models can encode structural and functional information of GPCR sequences that can be used to predict their signaling and functional repertoire. We used the ESM1b protein embeddings as features and the binding information known from publicly available studies to develop PRECOGx, a machine learning predictor to explore GPCR interactions with G protein and β-arrestin,...
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