Article

Geometric-Evolutionary Deep Learning Decodes the Human GPCR-Metabolome Interactome and Enables Systematic De-Orphanization

2026-02-23

Abstract excerpt

G protein-coupled receptors (GPCRs) are the largest class of drug targets, yet hundreds of orphan GPCRs lack known endogenous ligands, limiting our understanding of human physiology and therapeutic development. Existing computational approaches often fail to generalize to these unseen targets due to a reliance on target-specific priors and linear feature integration. Here, we present G-LEAP, a deep learning framew...

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Literature Corpus work: 7538e612-6665-5196-b402-f0c72bc00534
DOI: 10.64898/2026.02.21.707232

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