Article

BravizineDSE: A Multi-Input Deep Transformer for Receptor-Context-Aware GPCR Signaling Bias Prediction and Derivation of a Six-Feature Molecular Selectivity Rule

2026-03-13

Abstract excerpt

<title>Abstract</title> <p>G protein-coupled receptors (GPCRs) transduce signals through at least two structurally and functionally distinct pathways—G-protein activation and β-arrestin recruitment—whose selective engagement determines both therapeutic efficacy and side-effect liability. Despite the clinical importance of pathway-selective (“biased”) agonism, no publicly available computational tool has integrate...

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Literature Corpus work: f0abb4a3-2892-5c29-b078-ed8edb5a907e
DOI: 10.21203/rs.3.rs-9100474/v1

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