Article

DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings

2025-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Peptide-activated G protein-coupled receptors (GPCRs) regulate critical physiological processes such as metabolism, neural signalling, and endocrine function through their interaction with neuropeptides and peptide hormones. Despite their importance, identifying endogenous peptide agonists for GPCRs remains challenging, particularly for orphan receptors without known ligands. Recent advances in...

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Literature Corpus work: bf999238-7897-5239-8f22-fc41d94a1aa0
DOI: 10.1101/2025.03.19.644234

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