Article

Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis

2025-09-21

Abstract excerpt

<h4>Summary</h4> G protein-coupled receptors (GPCRs) mediate a variety of signaling pathways and are the most common pharmacological targets. While advances in structural biochemistry have provided deep functional insights into key receptors, many of the 800+ human GPCRs remain understudied. We introduce a versatile “deep receptor scanning” platform that can be used to experimentally characterize 766 human GPCRs...

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Literature Corpus work: b5e5bee6-7a25-53df-bcec-c0d65561fd07
DOI: 10.1101/2025.09.19.677468

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