FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking.

Abstract excerpt

Fusion oncoproteins, a class of chimeric proteins arising from chromosomal translocations, are major drivers of various pediatric cancers. These proteins are intrinsically disordered and lack druggable pockets, making them highly challenging therapeutic targets for both small molecule-based and structure-based approaches. Protein language models (pLMs) have recently emerged as powerful tools for capturing...

Topics

• Oncogene Proteins, Fusion
• Humans
• Neoplasms
• Mutation
• Drug Resistance, Neoplasm