Article

Genome-wide Prediction of Small Molecule Binding to Remote Orphan Proteins Using Distilled Sequence Alignment Embedding

2020-08-05

Abstract excerpt

Endogenous or surrogate ligands of a vast number of proteins remain unknown. Identification of small molecules that bind to these orphan proteins will not only shed new light into their biological functions but also provide new opportunities for drug discovery. Deep learning plays an increasing role in the prediction of chemical-protein interactions, but it faces several challenges in protein deorphanization. Bioa...

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Literature Corpus work: dc0d1730-c7ee-5e61-a6fa-3cde47ad32ea
DOI: 10.1101/2020.08.04.236729

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