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Article

Acylcarnitines and Genetic Variation in Fat Oxidation Genes in HIV-infected, Antiretroviral-treated Children With and Without Myopathy.

The Pediatric infectious disease journal - 1 Aug 2022

Kirmse Brian, Hobbs Charlotte, Aaron Lisa, Montepiedra Grace, Summar Marshall, Williams Paige L, Smith Caitlin J, Van Dyke Russell, Yu Chunli, Ryckman Kelli K, Borkowsky William

Abstract excerpt

BACKGROUND: Mitochondrial toxicity resulting in myopathy and lactic acidosis has been described in antiretroviral (ARV)-exposed patients. We hypothesized that myopathy in HIV-infected, ARV-treated children would be associated with metabolic (acylcarnitines) and genetic (variants in metabolic genes) markers of dysfunctional fatty acid oxidation (FAO). METHODS: Acylcarnitine profiles (ACP) were analyzed for 74...

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Identifiers

PMID: 35622436
DOI: 10.1097/INF.0000000000003586
PMCID: PMC9288497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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