Article
The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study.
BMC medical genetics - 27 Apr 2009
Shaboodien Gasnat, Engel Mark E, Syed Faisal F, Poulton Joanna, Badri Motasim, Mayosi Bongani M
Abstract excerpt
BACKGROUND: The mitochondrial DNA (mtDNA) T16189C polymorphism, with a homopolymeric C-tract of 10-12 cytosines, is a putative genetic risk factor for idiopathic dilated cardiomyopathy in the African and British populations. We hypothesized that this variant may predispose to dilated cardiomyopathy in people who are infected with the human immunodeficiency virus (HIV). METHODS: A case-control study of 30...
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