Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy.

The Journal of infectious diseases - 15 Mar 2008

Hulgan Todd, Tebas Pablo, Canter Jeffrey A, Mulligan Kathleen, Haas David W, Dubé Michael, Grinspoon Steven, Robbins Gregory K, Motsinger Alison A, Kallianpur Asha R

Abstract excerpt

BACKGROUND: Antiretroviral therapy (ART)-associated lipoatrophy involves mitochondrial dysfunction. Iron metabolism impacts mitochondrial function and oxidative stress. Mitochondrial haplogroups and hemochromatosis gene (HFE) polymorphisms have been associated with ART-induced neuropathy. We assessed relationships between these variants and lipoatrophy. METHODS: The AIDS Clinical Trials Group 384 study randomized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Absorptiometry, Photon
Share to Anti-Retroviral Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Genotype

Share to Hemochromatosis

Share to HIV Infections

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 18419350
DOI: 10.1086/528697

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy.PMID 18419350Read ↗

Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy.Semantic proximity Read ↗

Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study.Semantic proximity Read ↗

European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142*Semantic proximity Read ↗

Pharmacogenetics of Nucleoside Reverse-Transcriptase Inhibitor-Associated Peripheral NeuropathySemantic proximity Read ↗

Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy.Semantic proximity Read ↗

Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy.Semantic proximity Read ↗

Mitochondrial DNA haplogroups and incidence of lipodystrophy in HIV-infected patients on long-term antiretroviral therapy.Semantic proximity Read ↗

Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation.Semantic proximity Read ↗

Higher iron stores and the HFE 187C>G variant delay onset of peripheral neuropathy during combination antiretroviral therapy.Semantic proximity Read ↗

The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy.Semantic proximity Read ↗

Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIVSemantic proximity Read ↗

Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.