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Article

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

PloS one - 21 Sept 2010

Hendrickson Sher L, Lautenberger James A, Chinn Leslie Wei, Malasky Michael, Sezgin Efe, Kingsley Lawrence A, Goedert James J, Kirk Gregory D, Gomperts Edward D, Buchbinder Susan P, Troyer Jennifer L, O'Brien Stephen J

Abstract excerpt

BACKGROUND: The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20877624
DOI: 10.1371/journal.pone.0012862
PMCID: PMC2943476

Genes

ACSM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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