Article
Pharmacogenetics of the lipodystrophy syndrome associated with HIV infection and combination antiretroviral therapy.
Expert opinion on drug metabolism & toxicology - 1 Nov 2011
Vidal Francesc, Domingo Pere, Viladés Consuelo, Peraire Joaquim, Arnedo Mireia, Alcamí José, Leal Manuel, Villarroya Francesc, Gatell Josep Ma
Abstract excerpt
INTRODUCTION: Antiretroviral drugs have been associated with several toxicities that limit their success. Of the chronic toxicities, the lipodystrophy syndrome is of special concern due to the metabolic alterations that can accompany it. Why some patients treated with a particular antiretroviral regimen develop lipodystrophy, while others do not, is a medical mystery, but it has been suggested that individuals...
Topics
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Drug Therapy, Combination
- Genetic Predisposition to Disease
- HIV
- HIV Infections
- Humans
- Lipodystrophy