Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes.

Journal of translational medicine - 26 May 2022

Al-Farsi Halema, Al-Azwani Iman, Malek Joel A, Chouchane Lotfi, Rafii Arash, Halabi Najeeb M

Abstract excerpt

BACKGROUND: Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are essential to tumor development could lead to new therapeutic strategies. The recent advent of high-throughput whole genome sequencing being applied to many different samples has made it possible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Mutation

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35619151
DOI: 10.1186/s12967-022-03440-5
PMCID: PMC9134657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes.PMID 35619151Read ↗

Mutation status coupled with RNA-sequencing data can efficiently identify important non-significantly mutated genes serving as diagnostic biomarkers of endometrial cancer.Semantic proximity Read ↗

The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment.Semantic proximity Read ↗

Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.Semantic proximity Read ↗

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Semantic proximity Read ↗

Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer.Semantic proximity Read ↗

Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer.Semantic proximity Read ↗

Cellular Mechanism of Gene Mutations and Potential Therapeutic Targets in Ovarian CancerSemantic proximity Read ↗

A global transcriptional network connecting noncoding mutations to changes in tumor gene expression.Semantic proximity Read ↗

Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes.Semantic proximity Read ↗

The Clinical Significance of Genetic Variation in Ovarian Cancer.Semantic proximity Read ↗

Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.