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Article

A global transcriptional network connecting noncoding mutations to changes in tumor gene expression.

Nature genetics - 1 Apr 2018

Zhang Wei, Bojorquez-Gomez Ana, Velez Daniel Ortiz, Xu Guorong, Sanchez Kyle S, Shen John Paul, Chen Kevin, Licon Katherine, Melton Collin, Olson Katrina M, Yu Michael Ku, Huang Justin K, Carter Hannah, Farley Emma K, Snyder Michael, Fraley Stephanie I, Kreisberg Jason F, Ideker Trey

Abstract excerpt

Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. Here we perform an integrative analysis of 930 tumor whole genomes and matched transcriptomes, identifying a network of 193 noncoding loci in which mutations disrupt target gene expression. These 'somatic eQTLs' (expression quantitative trait loci) are frequently mutated in specific cancer...

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Identifiers

PMID: 29610481
DOI: 10.1038/s41588-018-0091-2
PMCID: PMC5893414

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DAAM1
HYI
MTG2

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