Article
Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.
PloS one - 1 Jan 2013
Birkbak Nicolai Juul, Kochupurakkal Bose, Izarzugaza Jose M G, Eklund Aron C, Li Yang, Liu Joyce, Szallasi Zoltan, Matulonis Ursula A, Richardson Andrea L, Iglehart J Dirk, Wang Zhigang C
Abstract excerpt
BACKGROUND: Increased number of single nucleotide substitutions is seen in breast and ovarian cancer genomes carrying disease-associated mutations in BRCA1 or BRCA2. The significance of these genome-wide mutations is unknown. We hypothesize genome-wide mutation burden mirrors deficiencies in DNA repair and is associated with treatment outcome in ovarian cancer. METHODS AND RESULTS: The total number of synonymous...
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