Article

Systemic immune dysfunction in cancer patients driven by IL6 and IL8 induction of an inhibitory receptor module in peripheral CD8 <sup>+</sup> T cells

2020-05-08

Abstract excerpt

Many cancer patients do not develop a durable response to the current standard of care immunotherapies despite substantial advances in targeting immune inhibitory receptors 1-5 . A potential compounding issue, which may serve as an unappreciated, dominant resistance mechanism, is an inherent systemic immune dysfunction that is often associated with advanced cancer 6-12 . Minimal response to inhibitory receptor (...

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Literature Corpus work: 086fcfe5-f6cb-5f5e-97bf-362165f9251b
DOI: 10.1101/2020.05.06.081471

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