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Disruption in <i>CYLC1</i> leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

2024-01-12

Abstract excerpt

The perinuclear theca (PT) is a dense cytoplasmic web encapsulating the sperm nucleus. The physiological roles of PT in sperm biology and the clinical relevance of variants of PT proteins to male infertility are still largely unknown. We reveal that cylicin-1, a major constituent of the PT, is vital for male fertility in both mice and humans. Loss of cylicin-1 in mice leads to a high incidence of malformed sperm h...

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Literature Corpus work
53f63a9a-efd9-5682-bd95-fff8ccfd577f
DOI
10.1101/2024.01.11.24301040
Open publication

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Disruption in <i>CYLC1</i> leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and miceDOI 10.1101/2024.01.11.24301040
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