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Article

PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis

11 Aug 2022

Abstract excerpt

Profilin 4 (Pfn4) is expressed during spermiogenesis and localizes to the acrosome-acroplaxome-manchette complex. Here, we generated PFN4-deficient mice, with sperm displaying severe impairment in manchette formation. Interestingly, HOOK1 staining suggests that the perinuclear ring is established; however, ARL3 staining is disrupted, suggesting that lack of PFN4 does not interfere with the formation of the...

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PMID: 35950913
DOI: 10.1242/dev.200499

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