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E-site drug specificity of the human pathogen Candida albicans ribosome

25 May 2022

Abstract excerpt

Candida albicans is a widespread commensal fungus with substantial pathogenic potential and steadily increasing resistance to current antifungal drugs. It is known to be resistant to cycloheximide (CHX) that binds to the E–transfer RNA binding site of the ribosome. Because of lack of structural information, it is neither possible to understand the nature of the resistance nor to develop novel inhibitors. To...

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PMID: 35613268
DOI: 10.1126/sciadv.abn1062

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