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Ribosome protection by antibiotic resistance ATP-binding cassette protein

30 Apr 2018

Abstract excerpt

The ribosome is one of the richest targets for antibiotics. Unfortunately, antibiotic resistance is an urgent issue in clinical practice. Several ATP-binding cassette family proteins confer resistance to ribosome-targeting antibiotics through a yet unknown mechanism. Among them, MsrE has been implicated in macrolide resistance. Here, we report the cryo-EM structure of ATP form MsrE bound to the ribosome. Unlike...

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PMID: 29712846
DOI: 10.1073/pnas.1803313115

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