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Sarecycline inhibits protein translation inCutibacterium acnes70S ribosome using a two-site mechanism

2 Mar 2023

Abstract excerpt

Acne vulgaris is a chronic disfiguring skin disease affecting ∼1 billion people worldwide, often having persistent negative effects on physical and mental health. The Gram-positive anaerobe, Cutibacterium acnes is implicated in acne pathogenesis and is, therefore, a main target for antibiotic-based acne therapy. We determined a 2.8-Å resolution structure of the 70S ribosome of Cutibacterium acnes by cryogenic...

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PMID: 36864821
DOI: 10.1093/nar/gkad103

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