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Article

Structure of the translating Neurospora ribosome arrested by cycloheximide.

Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2021

Shen Lunda, Su Zhaoming, Yang Kailu, Wu Cheng, Becker Thomas, Bell-Pedersen Deborah, Zhang Junjie, Sachs Matthew S

Abstract excerpt

Ribosomes translate RNA into proteins. The protein synthesis inhibitor cycloheximide (CHX) is widely used to inhibit eukaryotic ribosomes engaged in translation elongation. However, the lack of structural data for actively translating polyribosomes stalled by CHX leaves unanswered the question of which elongation step is inhibited. We elucidated CHX's mechanism of action based on the cryo-electron microscopy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34815343
DOI: 10.1073/pnas.2111862118
PMCID: PMC8640747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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