Article
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers.
PloS one - 1 Jan 2015
Pont-Sunyer Claustre, Iranzo Alex, Gaig Carles, Fernández-Arcos Ana, Vilas Dolores, Valldeoriola Francesc, Compta Yaroslau, Fernández-Santiago Ruben, Fernández Manel, Bayés Angels, Calopa Matilde, Casquero Pilar, de Fàbregues Oriol, Jaumà Serge, Puente Victor, Salamero Manel, José Martí Maria, Santamaría Joan, Tolosa Eduard
Abstract excerpt
OBJECTIVE: In idiopathic Parkinson disease (IPD) sleep disorders are common and may antedate the onset of parkinsonism. Based on the clinical similarities between IPD and Parkinson disease associated with LRRK2 gene mutations (LRRK2-PD), we aimed to characterize sleep in parkinsonian and nonmanifesting LRRK2 mutation carriers (NMC). METHODS: A comprehensive interview conducted by sleep specialists, validated...
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