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Article

LRRK2G2019S Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

Journal of cachexia, sarcopenia and muscle - 1 Dec 2024

Hu Yiying, Yang Huijia, Song Chunli, Tian Lulu, Wang Panpan, Li Tianbai, Cheng Cheng, AlNusaif Murad, Li Song, Liang Zhanhua, Le Weidong

Abstract excerpt

BACKGROUND: While the gradually aggravated motor and non-motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine-rich repeat kinase2 (LRRK2) is a common disease-causing gene in PD. Little is known about its role in skeletal muscle impairment and its underlying mechanisms. METHODS: To investigate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39310961
DOI: 10.1002/jcsm.13604
PMCID: PMC11634472

Genes

TG
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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