Article

Circadian clock disruption promotes the degeneration of dopaminergic neurons

2022-10-17

Abstract excerpt

Sleep and circadian rhythm disruptions are frequent comorbidities of Parkinson’s disease (PD), a disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. Although sleep/circadian disturbances can be observed years before diagnosing PD, it remains unclear whether circadian clocks have a causal role in the degenerative process. We demonstrated here that circadian clocks re...

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Literature Corpus work: 54ee2a15-87ac-5224-99a6-996a85f96788
DOI: 10.1101/2022.10.15.512376

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