Article
Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women.
Blood - 28 Aug 2025
Pershad Yash, Uddin Md Mesbah, Xue Liying, Haessler Jeffrey, Collins Jason M, Mack Taralynn M, Glick Elena, Glaser Veronica, Zhao Kun, Jaiswal Siddhartha, Manson JoAnn E, Pandey Urvashi, Desai Pinkal, Natarajan Pradeep, Honigberg Michael C, Kooperberg Charles, Whitsel Eric A, Kitzman Jacob O, Bick Alexander G, Reiner Alexander P
Abstract excerpt
ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants of clonal expansion remain poorly understood. We performed sequencing at a depth of coverage of >4000× for CHIP mutations in 6976 postmenopausal women from the Women's Health Initiative (WHI) at 2 time points: the WHI baseline examination and ∼16 years later at the Long...
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