Article
Understanding the Influence of Target Acquisition on Survival, Integration, and Phenotypic Maturation of Dopamine Neurons within Stem Cell-Derived Neural Grafts in a Parkinson's Disease Model.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Jun 2022
Moriarty Niamh, Kauhausen Jessica A, Pavan Chiara, Hunt Cameron P J, de Luzy Isabelle R, Penna Vanessa, Ermine Charlotte M, Thompson Lachlan H, Parish Clare L
Abstract excerpt
Midbrain dopaminergic (DA) neurons include many subtypes characterized by their location, connectivity and function. Surprisingly, mechanisms underpinning the specification of A9 neurons [responsible for motor function, including within ventral midbrain (VM) grafts for treating Parkinson's disease (PD)] over adjacent A10, remains largely speculated. We assessed the impact of synaptic targeting on survival,...
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