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Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.

Stem cells translational medicine - 1 Mar 2017

Niclis Jonathan C, Gantner Carlos W, Alsanie Walaa F, McDougall Stuart J, Bye Chris R, Elefanty Andrew G, Stanley Edouard G, Haynes John M, Pouton Colin W, Thompson Lachlan H, Parish Clare L

Abstract excerpt

Recent studies have shown evidence for the functional integration of human pluripotent stem cell (hPSC)-derived ventral midbrain dopamine (vmDA) neurons in animal models of Parkinson's disease. Although these cells present a sustainable alternative to fetal mesencephalic grafts, a number of hurdles require attention prior to clinical translation. These include the persistent use of xenogeneic reagents and...

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PMID: 28297587
DOI: 10.5966/sctm.2016-0073
PMCID: PMC5442782

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PITX3
FOXA2
OTX2

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