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Article

IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.

Oncoimmunology - 20 Aug 2020

Richardson Leland G, Nieman Linda T, Stemmer-Rachamimov Anat O, Zheng Xijin S, Stafford Khalifa, Nagashima Hiroaki, Miller Julie J, Kiyokawa Juri, Ting David T, Wakimoto Hiroaki, Cahill Daniel P, Choi Bryan D, Curry William T

Abstract excerpt

The metabolic gene isocitrate dehydrogenase 1 (IDH1) is commonly mutated in lower grade glioma (LGG) and secondary glioblastoma (GBM). Regulatory T cells (Tregs) play a significant role in the suppression of antitumor immunity in human glioma. Given the importance of Tregs in the overall framework of designing immune-based therapies, a better understanding on their association with IDH mutational status remains...

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Identifiers

PMID: 32923170
DOI: 10.1080/2162402X.2020.1806662
PMCID: PMC7458656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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