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Article

IDH1 Mutant Glioma Favors Group 3 Innate Lymphoid Cells and Is Resistant to Immune Checkpoint Expression.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Apr 2026

Erdem Serife, Haliloglu Yesim, Uslu Inayet Nur, Houran Mohammad, Ulutabanca Halil, Vural Alperen, Erturhan Mehmet Berat, Canatan Halit, Eken Ahmet

Abstract excerpt

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutations confer distinct biological properties to gliomas, including the reshaping of the tumor immune microenvironment. While T cell dysfunction in glioblastoma has been extensively characterized, the role of innate lymphoid cells (ILCs)-critical regulators of tissue homeostasis and early immune responses- remains poorly understood. METHODS: We investigated how IDH1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41917320
DOI: 10.1007/s00011-026-02223-8
PMCID: PMC13038673

Genes

IDH1
KLRG1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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