Article
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Nature genetics - 1 Aug 2018
Waage Johannes, Standl Marie, Curtin John A, Jessen Leon E, Thorsen Jonathan, Tian Chao, Schoettler Nathan, Flores Carlos, Abdellaoui Abdel, Ahluwalia Tarunveer S, Alves Alexessander C, Amaral Andre F S, Antó Josep M, Arnold Andreas, Barreto-Luis Amalia, Baurecht Hansjörg, van Beijsterveldt Catharina E M, Bleecker Eugene R, Bonàs-Guarch Sílvia, Boomsma Dorret I, Brix Susanne, Bunyavanich Supinda, Burchard Esteban G, Chen Zhanghua, Curjuric Ivan, Custovic Adnan, den Dekker Herman T, Dharmage Shyamali C, Dmitrieva Julia, Duijts Liesbeth, Ege Markus J, Gauderman W James, Georges Michel, Gieger Christian, Gilliland Frank, Granell Raquel, Gui Hongsheng, Hansen Torben, Heinrich Joachim, Henderson John, Hernandez-Pacheco Natalia, Holt Patrick, Imboden Medea, Jaddoe Vincent W V, Jarvelin Marjo-Riitta, Jarvis Deborah L, Jensen Kamilla K, Jónsdóttir Ingileif, Kabesch Michael, Kaprio Jaakko, Kumar Ashish, Lee Young-Ae, Levin Albert M, Li Xingnan, Lorenzo-Diaz Fabian, Melén Erik, Mercader Josep M, Meyers Deborah A, Myers Rachel, Nicolae Dan L, Nohr Ellen A, Palviainen Teemu, Paternoster Lavinia, Pennell Craig E, Pershagen Göran, Pino-Yanes Maria, Probst-Hensch Nicole M, Rüschendorf Franz, Simpson Angela, Stefansson Kari, Sunyer Jordi, Sveinbjornsson Gardar, Thiering Elisabeth, Thompson Philip J, Torrent Maties, Torrents David, Tung Joyce Y, Wang Carol A, Weidinger Stephan, Weiss Scott, Willemsen Gonneke, Williams L Keoki, Ober Carole, Hinds David A, Ferreira Manuel A, Bisgaard Hans, Strachan David P, Bønnelykke Klaus
Abstract excerpt
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic...
Read the complete abstract on PubMed