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Simple IHC reveals complex MMR alternations than PCR assays: Validation by LCM and next‐generation sequencing

21 May 2022

Abstract excerpt

Evaluation of the status of mismatch repair (MMR) in tumors is crucial for determining the application of immune checkpoint inhibitors (ICIs). Conventional PCR (MSI-PCR) is the gold standard for confirming the MMR status. However, it requires visual confirmation and presents difficulties in determining MMR status. Immunohistochemistry (IHC) is a simple method and can confirming MMR protein expression in the whole...

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PMID: 35596629
DOI: 10.1002/cam4.4832

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