Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microsatellite Status Detection in Gastrointestinal Cancers: PCR/NGS Is Mandatory in Negative/Patchy MMR Immunohistochemistry

28 Apr 2022

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) is a predictive biomarker for immune checkpoint inhibitors. The main goal was to investigate the discordance between IHC and PCR/NGS for MSI testing in gastrointestinal cancers. METHODS: Two series were analyzed through IHC for mismatch-repair-system proteins (MMRP) and PCR, with one series of 444 colorectal cancers (CRC) and the other of 176 gastric cancers (GC). All...

Topics

Join the communities discussing this publication.

Cancer Immunotherapy and Biomarkers
Colorectal Cancer Treatments and Studies
Genetic factors in colorectal cancer

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35565332
DOI: 10.3390/cancers14092204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microsatellite Status Detection in Gastrointestinal Cancers: PCR/NGS Is Mandatory in Negative/Patchy MMR ImmunohistochemistryPMID 35565332Read ↗

Concordance in detection of microsatellite instability by PCR and NGS in routinely processed tumor specimens of several cancer typesSemantic proximity Read ↗

Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer seriesSemantic proximity Read ↗

The Day-To-Day Practice of MMR and MSI Assessment in Colorectal Adenocarcinoma: What We Know and What We Still Need to ExploreSemantic proximity Read ↗

Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms.Semantic proximity Read ↗

Potent therapeutic strategy in gastric cancer with microsatellite instability-high and/or deficient mismatch repairSemantic proximity Read ↗

Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?Semantic proximity Read ↗

Clinicopathological features of mismatch repair protein expression patterns in colorectal cancer.Semantic proximity Read ↗

Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processesSemantic proximity Read ↗

Comprehensive Study of Microsatellite Instability Testing and Its Comparison With Immunohistochemistry in Gastric CancersSemantic proximity Read ↗

Mismatch Repair Protein Loss as a Prognostic and Predictive Biomarker in Breast Cancers Regardless of Microsatellite InstabilitySemantic proximity Read ↗

Analysis of Concordance Between Next-Generation Sequencing Assessment of Microsatellite Instability and Immunohistochemistry-Mismatch Repair From Solid TumorsSemantic proximity Read ↗

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.