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Validation of Long Mononucleotide Repeat Markers for Detection of Microsatellite Instability

2 Dec 2021

Abstract excerpt

Mismatch repair deficiency (dMMR) predicts response to immune checkpoint inhibitor therapy in solid tumors. Long mononucleotide repeat (LMR) markers may improve the interpretation of microsatellite instability (MSI) assays. Our cohorts included mismatch repair (MMR) proficient and dMMR colorectal cancer (CRC) samples, MMR proficient and dMMR endometrial cancer (EC) samples, dMMR prostate cancer samples, MSI-high...

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PMID: 34864149
DOI: 10.1016/j.jmoldx.2021.10.011

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