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Article

A disease- and phosphorylation-related nonmechanical function for keratin 8.

The Journal of cell biology - 3 Jul 2006

Ku Nam-On, Omary M Bishr

Abstract excerpt

Keratin 8 (K8) variants predispose to human liver injury via poorly understood mechanisms. We generated transgenic mice that overexpress the human disease-associated K8 Gly61-to-Cys (G61C) variant and showed that G61C predisposes to liver injury and apoptosis and dramatically inhibits K8 phosphorylation at serine 73 (S73) via stress-activated kinases. This led us to generate mice that overexpress K8 S73-to-Ala...

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Identifiers

PMID: 16818723
DOI: 10.1083/jcb.200602146
PMCID: PMC2064169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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