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Article

Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer.

Aging cell - 1 Jun 2022

Gupta Pooja, Majumdar Ananda Guha, Patro Birija Sankar

Abstract excerpt

Mutation in Werner (WRN) RECQL helicase is associated with premature aging syndrome (Werner syndrome, WS) and predisposition to multiple cancers. In patients with solid cancers, deficiency of the WRN RECQL helicase is paradoxically associated with enhanced overall survival in response to treatment with TOP1 inhibitors, which stabilize pathological TOP1-DNA-covalent-complexes (TOP1cc) on the genome. However, the...

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Identifiers

PMID: 35582959
DOI: 10.1111/acel.13625
PMCID: PMC9197415

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