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Article

RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.

Cell cycle (Georgetown, Tex.) - 15 Aug 2008

Seki Masayuki, Otsuki Makoto, Ishii Yutaka, Tada Shusuke, Enomoto Takemi

Abstract excerpt

Cells of all living organisms have evolved complex mechanisms to maintain genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication. RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. In human cells, there exist five RecQ DNA helicases, and mutations of three of these helicases, encoded by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18719387
DOI: 10.4161/cc.7.16.6462

Genes

BLM
RECQL4
RECQL5
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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