Article

Anticipating on-target resistance to WRN inhibitors in microsatellite unstable cancers

2026-01-24

Abstract excerpt

Leveraging WRN helicase dependency in microsatellite instability (MSI) cancers offers a synthetic lethal (SL) therapeutic opportunity, with several WRN inhibitors in development. However, the hypermutator nature of MSI tumors creates strong evolutionary pressure for rapid resistance. Here, we apply a multimodal functional genomics framework integrating base editing screens and deep mutational scanning to map on-ta...

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Literature Corpus work: 51c301ea-1997-5dba-896f-7afb775d9f1d
DOI: 10.64898/2026.01.22.700152

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