Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation and cognitive functioning in healthy older adults.

The British journal of nutrition - 1 Mar 2012

Schiepers Olga J G, van Boxtel Martin P J, de Groot Renate H M, Jolles Jelle, Kok Frans J, Verhoef Petra, Durga Jane

Abstract excerpt

Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognitive Dysfunction
Share to Cytosine
Share to Double-Blind Method

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Folic Acid Deficiency

Share to Homocysteine

Share to Leukocytes

Share to Psychiatric Status Rating Scales

Source

Identifiers

PMID: 21791146
DOI: 10.1017/S0007114511003576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation and cognitive functioning in healthy older adults.PMID 21791146Read ↗

Genetic variation in folate metabolism is not associated with cognitive functioning or mood in healthy adults.Semantic proximity Read ↗

Blood-based epigenome-wide analyses of cognitive abilitiesSemantic proximity Read ↗

Age-related changes in the global DNA methylation profile of leukocytes are linked to nutrition but are not associated with the MTHFR C677T genotype or to functional capacities.Semantic proximity Read ↗

DNA methylation in the APOE genomic region is associated with cognitive function in African Americans.Semantic proximity Read ↗

APOE gene region methylation is associated with cognitive performance in middle-aged urban adults.Semantic proximity Read ↗

DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.Semantic proximity Read ↗

Folate and the methylenetetrahydrofolate reductase 677C-->T mutation correlate with cognitive performance.Semantic proximity Read ↗

Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1Semantic proximity Read ↗

No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine.Semantic proximity Read ↗

Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementiaSemantic proximity Read ↗

Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.Semantic proximity Read ↗

Cardiovascular disease attenuates the protective effect of folate on global cognitive function in an elderly population: a cross-sectional studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.