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VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection

10 May 2022

Abstract excerpt

β-coronaviruses reshape host cell endomembranes to form double-membrane vesicles (DMVs) for genome replication and transcription. Ectopically expressed viral nonstructural proteins nsp3 and nsp4 interact to zipper and bend the ER for DMV biogenesis. Genome-wide screens revealed the autophagy proteins VMP1 and TMEM41B as important host factors for SARS-CoV-2 infection. Here, we demonstrated that DMV biogenesis,...

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PMID: 35536318
DOI: 10.1083/jcb.202112081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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