Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-scale CRISPR screen identifies TMEM198 driving double membrane vesicle formation in swine alphacoronavirus and murine betacoronavirus infected cells

30 May 2025

Abstract excerpt

COVID-19 pandemic caused by the SARS-CoV-2 which is well-publicized cross-species transmissibility. SARS-CoV-2 belongs to genus Betacoronavirus, several pathogenic alphacoronaviruses have shown similar patterns of emergence. Much less attention paid to host factors required for alphacoronavirus replication compared to those of betacoronaviruses. Here, we utilized a genome-wide CRISPR-Cas9-based screen to identify...

Topics

Join the communities discussing this publication.

Animal Virus Infections Studies
SARS-CoV-2 and COVID-19 Research
Viral Infections and Immunology Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40446005
DOI: 10.1371/journal.ppat.1013211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-scale CRISPR screen identifies TMEM198 driving double membrane vesicle formation in swine alphacoronavirus and murine betacoronavirus infected cellsPMID 40446005Read ↗

A Comprehensive Review of Coronavirus Non-Structure Protein 6 on Structure, Functions, Mechanisms and Its Implications for Antiviral Research.Semantic proximity Read ↗

Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replicationSemantic proximity Read ↗

The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission.Semantic proximity Read ↗

Membrane remodeling by SARS-CoV-2 – double-enveloped viral replicationSemantic proximity Read ↗

VPS29 exerts opposing effects on endocytic viral entrySemantic proximity Read ↗

YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formationSemantic proximity Read ↗

A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomesSemantic proximity Read ↗

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infectionSemantic proximity Read ↗

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronavirusesSemantic proximity Read ↗

Identification of key host genes for influenza A virus in avian cells using a genome-wide CRISPR-Cas9 screenSemantic proximity Read ↗

VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infectionSemantic proximity Read ↗

Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.