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Article

A Comprehensive Review of Coronavirus Non-Structure Protein 6 on Structure, Functions, Mechanisms and Its Implications for Antiviral Research.

Viruses - 30 Jun 2026

Yu Yingzhe, He Weimei, Geng Xiaohui, He Yulong, Feng Huapeng, Chen Jian, Shu Jianhong

Abstract excerpt

Coronaviruses encode a variety of non-structural proteins (NSPs) that collectively mediate viral genome replication, transcription and remodeling of the host cellular microenvironment. As a highly conserved transmembrane protein, non-structural protein 6 (NSP6) predominantly localizes to the endoplasmic reticulum. Through interactions with other viral proteins and host factors, NSP6 participates in multiple...

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Identifiers

PMID: 42515573
DOI: 10.3390/v18070721
PMCID: PMC13431472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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