Article

Ribophorin-1 Governs Spike Abundance of Highly Pathogenic Coronaviruses by ER-associated degradation

2026-05-21

Abstract excerpt

The spike protein of highly pathogenic coronaviruses is indispensable for viral entry, pathogenesis, and immune evasion. However, specific host factors governing spike protein degradation and abundance on progeny virions remain largely uncharacterized. Here, we identify Ribophorin-1 (RPN1), a non-catalytic subunit of the oligosaccharyltransferase (OST) complex, as an ER-localized host restriction factor that selec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1931ae8d-f39a-56ba-93e7-c894474b3568
DOI: 10.64898/2026.05.20.726704

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ribophorin-1 Governs Spike Abundance of Highly Pathogenic Coronaviruses by ER-associated degradationDOI 10.64898/2026.05.20.726704Read

Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replicationSemantic proximity Read

A Comprehensive Review of Coronavirus Non-Structure Protein 6 on Structure, Functions, Mechanisms and Its Implications for Antiviral Research.Semantic proximity Read

SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathwaySemantic proximity Read

An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking.Semantic proximity Read

Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from EndosomesSemantic proximity Read

SARS-CoV-2 harnesses host translational shutoff and autophagy to optimize virus yields: The role of the envelope (E) proteinSemantic proximity Read

Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for ReplicationSemantic proximity Read

The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutationSemantic proximity Read

Tumor Susceptibility Gene 101 (TSG101) Contributes to Virion Formation of Porcine Reproductive and Respiratory Syndrome Virus via Interaction with the Nucleocapsid (N) Protein along with the Early Secretory PathwaySemantic proximity Read

The biogenesis of SARS-CoV-2 spike glycoprotein: multiple targets for host-directed antiviral therapySemantic proximity Read

The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infectionsSemantic proximity Read

MERS-CoV Nsp1 Impairs Cell Viability by Selectively Degrading the mRNAs of Ribosomal Protein Genes and Oxidative Phosphorylation GenesSemantic proximity Read