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Article

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection

8 Aug 2022

Abstract excerpt

Transmembrane Protein 41B (TMEM41B) and Vacuole Membrane Protein 1 (VMP1) are two ER-associated lipid scramblases that play a role in autophagosome formation and cellular lipid metabolism. TMEM41B is also a recently validated host factor required by flaviviruses and coronaviruses. However, the exact underlying mechanism of TMEM41B in promoting viral infections remains an open question. Here, we validated that...

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PMID: 35939522
DOI: 10.1371/journal.ppat.1010763

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