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The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission.

Virologica Sinica - 1 Apr 2025

Wang Pei, Tian Buyun, Xiao Ke, Ji Wei, Li Zonghong

Abstract excerpt

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in mutations not only in the spike protein, aiding immune evasion, but also in the NSP3/4/6 proteins, crucial for regulating double-membrane vesicle (DMV) formation. However, the functional consequences of these NSP3/4/6 mutations remain poorly understood. In this study, a systematic analysis was conducted to investigate...

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Chlorocebus aethiops
COVID-19
Endoplasmic Reticulum
Mutation
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

SARS-CoV-2 and COVID-19 Research

Viral Nonstructural Proteins

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Identifiers

PMID: 40157604
DOI: 10.1016/j.virs.2025.03.010
PMCID: PMC12131028

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