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Article

The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

13 Sept 2019

Abstract excerpt

Flaviviruses translate their genomes as multi-pass transmembrane proteins at the endoplasmic reticulum (ER) membrane. Here, we show that the ER membrane protein complex (EMC) is indispensable for the expression of viral polyproteins. We demonstrated that EMC was essential for accurate folding and post-translational stability rather than translation efficiency. Specifically, we revealed degradation of NS4A-NS4B, a...

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PMID: 31516121
DOI: 10.7554/elife.48469

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